Secobarbital has the highest degree of lipid solubility and thus the fastest distribution, phenobarbital is the least lipid soluble and has the slowest. Phenobarbital is an antiepileptic agent widely used for treatment partial and. Pentobarbital is a member of the class of barbiturates, the structure of which is that of barbituric acid substituted at c5 by ethyl and secpentyl groups. Unless otherwise indicated, all text within nci products is free of and. Accurately weigh and prepare a standard solution of phenobarbital free acid or sodium salt at approximately. The prophylactic use of phenobarbital in infants with febrile seizures has been challenged. Rifampin mayq metabolism of andpeffects of phenobarbital. Phenobarbital c12h12n2o3 cid 4763 structure, chemical names. Phenobarbital is a barbiturate, nonselective central nervous system depressant which is primarily used as a sedative hypnotic and also as an anticonvulsant in subhypnotic doses phenobarbital tablets and elixir are administered orally and are contained in dea schedule iv. High concentrations appear in the brain, liver and kidneys.
Phenobarbital sodium is a barbiturate that is the sodium salt of phenobarbital barbituric acid substituted at c5 by ethyl and phenyl groups. Each ml contains phenobarbital sodium either 65 mg or mg, alcohol 0. Phenobarbital, also known as phenobarbitone or phenobarb, is a medication recommended by the world health organization who for the treatment of certain types of epilepsy in developing countries. Barbiturates are substituted pyrimidine derivatives in which the basic. In the developed world, it is commonly used to treat seizures in young children, while other medications are generally used in older children and adults. Accurately weigh and prepare a standard solution of phenobarbital free acid at approximately 0.
Mayqrisk of hematologictoxicitywith cyclophosphamide. Phenobarbital also is useful in seizures caused by barbiturate withdrawal in dependent individuals. Phenobarbital sodium injection, usp is a sterile solution for intramuscular or slow intravenous administration as a longacting barbiturate. Slowly absorbed from gi tract following oral administration, b with peak plasma concentrations usually attained within 812 hours and peak brain concentrations in 1015 hours. Fenobarbital teva 25 mg, tabletten fenobarbital teva 50 mg. Phenobarbital, known by the brand names luminal and solfoton, is a medication used to control seizures, treat anxiety and insomnia, and prevent withdrawal symptoms in patients who.
Phenobarbital sodium injection usp page 3 of 21 once absorbed, phenobarbital is rapidly distributed to all tissues and fluids. Pdf on sep 1, 2008, m jelveghari and others published development and chemical stability studies of alcohol free phenobarbital solution for use in pediatrics. Phenobarbital, also known as phenobarbitone or phenobarb, is a medication recommended by. Concomitant use of kavakava,valerian chamomile,orhopscanqcnsdepression. Phenobarbital sodium pharmacokinetics absorption bioavailability. However, information on the commercial preparations not used at rhw is deleted. Phenobarbital phenobarbitone 2016 neonatal medicines formulary consensus group phenobarbital phenobarbitone page 1 of 4 this rhw document is a modification of neomed version. The sodium salt is administered parenterally as part of the treatment regimen for status epilepticus.
95 129 638 604 727 1212 359 5 604 393 1626 1215 338 251 1054 1536 1338 418 1266 1324 1396 451 1179 664 273 857 1365 455 189 539 1267 838 1244 556 202 1175 175 322 1306 157 758